You can use country, city, region, postal address or codes, iata airport codes, coordinates or what3words addresses.
The calculation takes max. one second per row.
If you need the distances from one single origin to other destinations you should copy&paste that origin to the first field of every row in your spreadsheet.
If you need distances from different origins to one single destination you should copy&paste that destination to the second field of every row in your spreadsheet.
A route describes every row in the spreadsheet containing origin and destination.